Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Identifieur interne : 000807 ( 2020/Analysis ); précédent : 000806; suivant : 000808Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Auteurs : Bruno Tilocca [Italie] ; Alessio Soggiu [Italie] ; Maurizio Sanguinetti [Italie] ; Vincenzo Musella [Italie] ; Domenico Britti [Italie] ; Luigi Bonizzi [Italie] ; Andrea Urbani [Italie] ; Paola Roncada [Italie]Source :
- Microbes and Infection [ 1286-4579 ] ; 2020.
Abstract
Several research lines are currently ongoing to address the multitude of facets of the pandemic COVID-19. In line with the One-Health concept, extending the target of the studies to the animals which humans are continuously interacting with may favor a better understanding of the SARS-CoV-2 biology and pathogenetic mechanisms; thus, helping to adopt the most suitable containment measures. The last two decades have already faced severe manifestations of the coronavirus infection in both humans and animals, thus, circulating epitopes from previous outbreaks might confer partial protection from SARS-CoV-2 infections. In the present study, we provide an
Url:
DOI: 10.1016/j.micinf.2020.04.002
PubMed: 32302675
PubMed Central: 7156246
Affiliations:
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PMC:7156246Le document en format XML
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Vito 1, 00168, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo S. Vito 1, 00168, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4">Dipartimento di Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli, Largo A. Gemelli 8, 00168, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli, Largo A. Gemelli 8, 00168, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Musella, Vincenzo" sort="Musella, Vincenzo" uniqKey="Musella V" first="Vincenzo" last="Musella">Vincenzo Musella</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, 88100, Catanzaro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, 88100, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Britti, Domenico" sort="Britti, Domenico" uniqKey="Britti D" first="Domenico" last="Britti">Domenico Britti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, 88100, Catanzaro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, 88100, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author><author><name sortKey="Bonizzi, Luigi" sort="Bonizzi, Luigi" uniqKey="Bonizzi L" first="Luigi" last="Bonizzi">Luigi Bonizzi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biomedical, Surgical and Dental Sciences– One Health Unit, University of Milano, Via Celoria n10, 20133, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical, Surgical and Dental Sciences– One Health Unit, University of Milano, Via Celoria n10, 20133, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Urbani, Andrea" sort="Urbani, Andrea" uniqKey="Urbani A" first="Andrea" last="Urbani">Andrea Urbani</name><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo S. Vito 1, 00168, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo S. Vito 1, 00168, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4">Dipartimento di Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli, Largo A. Gemelli 8, 00168, Roma, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli, Largo A. Gemelli 8, 00168, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Roncada, Paola" sort="Roncada, Paola" uniqKey="Roncada P" first="Paola" last="Roncada">Paola Roncada</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, 88100, Catanzaro, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, 88100, Catanzaro</wicri:regionArea><wicri:noRegion>Catanzaro</wicri:noRegion></affiliation></author></analytic><series><title level="j">Microbes and Infection</title><idno type="ISSN">1286-4579</idno><idno type="eISSN">1769-714X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Several research lines are currently ongoing to address the multitude of facets of the pandemic COVID-19. In line with the One-Health concept, extending the target of the studies to the animals which humans are continuously interacting with may favor a better understanding of the SARS-CoV-2 biology and pathogenetic mechanisms; thus, helping to adopt the most suitable containment measures. The last two decades have already faced severe manifestations of the coronavirus infection in both humans and animals, thus, circulating epitopes from previous outbreaks might confer partial protection from SARS-CoV-2 infections. In the present study, we provide an <italic>in-silico</italic> survey of the major nucleocapsid protein epitopes and compare them with the homologues of taxonomically-related coronaviruses with tropism for animal species that are closely inter-related with the human beings population all over the world. Protein sequence alignment provides evidence of high sequence homology for some of the investigated proteins. Moreover, structural epitope mapping by homology modelling revealed a potential immunogenic value also for specific sequences scoring a lower identity with SARS-CoV-2 nucleocapsid proteins. These evidence provide a molecular structural rationale for a potential role in conferring protection from SARS-CoV-2 infection and identifying potential candidates for the development of diagnostic tools and prophylactic-oriented strategies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhou, X" uniqKey="Zhou X">X. Zhou</name></author><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z. Wu</name></author><author><name sortKey="Yu, R" uniqKey="Yu R">R. Yu</name></author><author><name sortKey="Cao, S" uniqKey="Cao S">S. Cao</name></author><author><name sortKey="Fang, W" uniqKey="Fang W">W. Fang</name></author><author><name sortKey="Jiang, Z" uniqKey="Jiang Z">Z. 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Li</name></author><author><name sortKey="Bastien, N" uniqKey="Bastien N">N. Bastien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grifoni, A" uniqKey="Grifoni A">A. Grifoni</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J. Sidney</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Scheuermann, R H" uniqKey="Scheuermann R">R.H. Scheuermann</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B. Peters</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tilocca, B" uniqKey="Tilocca B">B. Tilocca</name></author><author><name sortKey="Soggiu, A" uniqKey="Soggiu A">A. Soggiu</name></author><author><name sortKey="Musella, V" uniqKey="Musella V">V. Musella</name></author><author><name sortKey="Britti, D" uniqKey="Britti D">D. Britti</name></author><author><name sortKey="Sanguinetti, M" uniqKey="Sanguinetti M">M. Sanguinetti</name></author><author><name sortKey="Urbani, A" uniqKey="Urbani A">A. Urbani</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Tilocca, Bruno" sort="Tilocca, Bruno" uniqKey="Tilocca B" first="Bruno" last="Tilocca">Bruno Tilocca</name></noRegion><name sortKey="Bonizzi, Luigi" sort="Bonizzi, Luigi" uniqKey="Bonizzi L" first="Luigi" last="Bonizzi">Luigi Bonizzi</name><name sortKey="Britti, Domenico" sort="Britti, Domenico" uniqKey="Britti D" first="Domenico" last="Britti">Domenico Britti</name><name sortKey="Musella, Vincenzo" sort="Musella, Vincenzo" uniqKey="Musella V" first="Vincenzo" last="Musella">Vincenzo Musella</name><name sortKey="Roncada, Paola" sort="Roncada, Paola" uniqKey="Roncada P" first="Paola" last="Roncada">Paola Roncada</name><name sortKey="Sanguinetti, Maurizio" sort="Sanguinetti, Maurizio" uniqKey="Sanguinetti M" first="Maurizio" last="Sanguinetti">Maurizio Sanguinetti</name><name sortKey="Sanguinetti, Maurizio" sort="Sanguinetti, Maurizio" uniqKey="Sanguinetti M" first="Maurizio" last="Sanguinetti">Maurizio Sanguinetti</name><name sortKey="Soggiu, Alessio" sort="Soggiu, Alessio" uniqKey="Soggiu A" first="Alessio" last="Soggiu">Alessio Soggiu</name><name sortKey="Urbani, Andrea" sort="Urbani, Andrea" uniqKey="Urbani A" first="Andrea" last="Urbani">Andrea Urbani</name><name sortKey="Urbani, Andrea" sort="Urbani, Andrea" uniqKey="Urbani A" first="Andrea" last="Urbani">Andrea Urbani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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